| Formulary Chapter 4: Central nervous system - Full Chapter
|
| 04.01 |
Hypnotics and anxiolytics |
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Temazepam
(hypnotic)
|
Formulary
 
|
|
|
|
| 04.01.01 |
Zaleplon, Zolpidem and Zopiclone |
|
|
Zolpidem
|
Formulary
|
|
 NICE TA77: Zaleplon, zolpidem and zopiclone for the management of insomnia
|
Zopiclone
|
 Restricted
|
|
NICE TA77: Zaleplon, zolpidem and zopiclone for the management of insomnia
|
| 04.01.01 |
Chloral and derivatives |
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|
| 04.01.01 |
Clomethiazole (Chlormethiazole) |
|
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|
| 04.01.02 |
Anxiolytics |
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Diazepam
(anxiety)
|
Formulary
|
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Lorazepam
(tablets )
|
Formulary
|
anxiety
|
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|
Lorazepam
(injection)
|
Formulary
|
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|
| 04.01.03 |
Barbiturates |
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|
| 04.02 |
Drugs used in psychoses and related disorders |
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|
| 04.02.01 |
Antipsychotic Drugs |
|
|
Zuclopenthixol
|
Formulary
|
|
|
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Trifluoperazine
|
Formulary
|
|
|
|
Zuclopenthixol Acetate
|
Formulary
|
LCFT ONLY
Clopixol Acuphase®
|
|
|
| 04.02.01 |
First-Generation Antipsychotic Drugs |
|
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Chlorpromazine
(tablets/liquids)
|
Formulary
|
|
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Haloperidol
(tablets/liquid)
|
Formulary
|
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Promazine Hydrochloride (Promazine®)
|
Formulary
|
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Fluphenazine Hydrochloride
|
Formulary
|
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|
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Haloperidol decanoate injection
|
Formulary
|
|
|
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Levomepromazine (Nozinan®)
|
Formulary
|
existing patients
Black (RAG) rating for new patients
|
|
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Haloperidol injection
|
Formulary
|
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|
| 04.02.01 |
Second-Generation Antipsychotic Drugs |
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Olanzapine tablets
|
Formulary
|
LCFT INITIATION ONLY
|
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Quetiapine
|
Formulary
|
LCFT INITIATION ONLY
tablets and XL tablets
|
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Risperidone
|
Formulary
|
LCFT INITIATION ONLY
|
|
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Amisulpride
|
Formulary
|
LCFT INITIATION ONLY
|
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Aripiprazole
|
Formulary
|
LCFT INITIATION ONLY
|
NICE TA213: Aripiprazole for the treatment of schizophrenia in people aged 15 -17 years
NICE TA292: Bipolar disorder (children) - aripiprazole
|
Clozapine
|
Formulary
|
LCFT ONLY
|
|
|
Lurasidone (Latuda®)
|
Formulary
|
LCFT ONLY
|
|
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Olanzapine injection
|
Formulary
|
LCFT ONLY
|
|
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Paliperidone (Invega®)
|
Formulary
|
LCFT ONLY
|
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|
| 04.02.02 |
Antipsychotic depot injections |
|
|
Flupentixol Decanoate
|
Formulary
|
LCFT INITIATION ONLY
Depixol®
|
|
|
Zuclopenthixol Decanoate
|
Formulary
|
LCFT INITIATION ONLY
|
|
|
Aripiprazole
|
Formulary
|
LCFT ONLY
Abilify Maintena®
|
|
|
Paliperidone palmitate
|
Formulary
|
LCFT ONLY
Xeplion®
|
|
|
Risperidone
|
Formulary
|
LCFT ONLY
Risperdal Consta®
|
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|
| 04.02.03 |
Drugs used for mania and hypomania |
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|
| 04.02.03 |
Antipsychotic drugs |
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|
| 04.02.03 |
Valproic acid |
|
|
Valproic Acid
|
Formulary
|
Depakote®
|
|
|
Sodium valproate
|
 Unlicensed
|
|
|
|
|
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Lithium Carbonate
|
Formulary
|
Priadel®
|
|
|
Lithium Citrate
|
Formulary
|
Priadel® Liquid
|
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|
| 04.03 |
Antidepressant drugs |
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|
| 04.03.01 |
Tricyclic and related antidepressant drugs |
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|
| 04.03.01 |
Tricyclic antidepressants |
|
|
Amitriptyline
(antidepressant)
|
Formulary
|
|
|
|
Clomipramine
|
Formulary
|
|
|
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Imipramine
|
Formulary
|
|
|
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Lofepramine
|
Formulary
|
|
|
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Doxepin
|
Formulary
|
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|
| 04.03.01 |
Related antidepressants |
|
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Trazodone
|
Formulary
|
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Mianserin
|
Formulary
|
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|
| 04.03.02 |
Monoamine-oxidase inhibitors |
|
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Phenelzine
|
Formulary
|
Nardil®
|
|
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|
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Moclobemide
|
Formulary
|
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|
|
| 04.03.03 |
Selective serotonin re-uptake inhibitors |
|
|
Citalopram
|
Formulary
|
|
|
|
Escitalopram
|
Restricted
|
Major depressive illness only
|
|
|
Fluoxetine
|
Formulary
|
|
|
|
Paroxetine
|
Formulary
|
|
|
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Sertraline
|
Formulary
|
|
|
|
Vortioxetine
|
Formulary
|
|
NICE TA367 - Vortioxetine for treating major depressive episodes
|
|
|
| 04.03.04 |
Other antidepressant drugs |
|
|
Mirtazapine
|
Formulary
|
|
|
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Venlafaxine
|
Formulary
|
|
|
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Duloxetine
|
Formulary
|
|
|
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Reboxetine
|
Formulary
|
Edronex®
|
|
|
| 04.04 |
CNS stimulants and other drugs used for attention deficit hyperactivity disorder |
|
|
Methylphenidate
|
Formulary
|
|
|
|
Methylphenidate Hydrochloride MR
|
Formulary
|
Equasym®
Medikinet®
Concerta®
|
|
|
Atomoxetine
|
Formulary
|
Strattera®
|
|
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Dexamfetamine
|
Formulary
|
|
|
|
Guanfacine
|
Formulary
|
Intuniv®
|
|
|
Lisdexamfetamine
|
Formulary
|
AMBER 1 for ADHD in adults
RED for ADHD in children and young adults
Elvanse®
|
|
|
Modafinil (Provigil®)
|
Formulary
|
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|
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|
| 04.05 |
Drugs used in the treatment of obesity |
|
|
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|
| 04.05.01 |
Anti-obesity drugs acting on the gastro-intestinal tract |
|
|
Orlistat
|
Restricted
|
|
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|
| 04.05.02 |
Centrally acting appetite suppressants |
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|
| 04.06 |
Drugs used in nausea and vertigo |
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|
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|
| 04.06 |
Vomiting during pregnancy |
|
|
| 04.06 |
Postoperative nausea and vomiting |
|
|
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|
| 04.06 |
Other vestibular disorders |
|
|
| 04.06 |
Cytotoxic chemotherapy |
|
|
|
|
Cyclizine
|
Formulary
|
|
|
|
Haloperidol
|
Formulary
|
|
|
|
Levomepromazine
|
Formulary
|
|
|
|
|
|
|
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Cinnarizine
|
Formulary
|
|
|
|
Cyclizine
|
Formulary
|
|
|
|
| 04.06 |
Phenothiazines and related drugs |
|
|
Prochlorperazine
|
Formulary
|
|
|
|
| 04.06 |
Domperidone and metoclopramide |
|
|
Metoclopramide
|
Formulary
|
|
|
|
Domperidone
|
Formulary
|
|
|
|
|
|
Granisetron
|
Formulary
|
|
|
|
Ondansetron
|
Restricted
|
NB off licence use as only licensed for post chemo/post operative use
|
|
|
| 04.06 |
Neurokinin receptor antagonist |
|
|
Aprepitant
|
Formulary
|
Emend®
|
|
|
Fosaprepitant
|
Formulary
|
Ivemend®
|
|
|
|
|
Cannabidiol 2.5mg/dose (Sativex oromucosal spray®)
|
Formulary
|
|
|
|
|
|
Hyoscine Hydrobromide
(tablets/patches)
|
Formulary
|
|
|
|
| 04.06 |
Other drugs for Ménière's disease |
|
|
Betahistine Dihydrochloride
|
Formulary
|
|
|
|
|
|
|
|
| 04.07.01 |
Non-opioid analgesics and compound analgesic preparations |
|
|
Paracetamol
|
Formulary
|
Drug included within CCG low priority prescribing policy. EXEMPTIONS EXIST FOR CERTAIN INDICATIONS. Please consult attached policy for list of excepted indications for prescribing of this drug.
|
|
|
| 04.07.01 |
Compound analgesic preparations |
|
|
Co-Codamol 30/500
|
Formulary
|
NOT for INPATIENT USE - use seperate components
Hospital - Emergency Department only
|
|
|
| 04.07.02 |
Opioid analgesics |
|
|
Dihydrocodeine
|
Formulary
|
|
|
|
Codeine
(analgesia)
|
Formulary
|
Injection Only
|
|
|
Diamorphine
|
Formulary
|
|
|
|
Fentanyl
|
Formulary
|
|
|
|
Morphine
|
Formulary
|
|
|
|
Oxycodone
|
Formulary
|
|
|
|
Pethidine
|
Formulary
|
|
|
|
|
|
| 04.07.03 |
Neuropathic pain |
|
|
Amitriptyline
|
Formulary
|
|
|
|
Capsaicin
|
Formulary
|
0.025% - Unlicensed in Neuropathic Pain
0.075% - Licensed for post-herpetic neuralgia after open skin lesions have healed and painful diabetic peripheral polyneuropathy
|
|
|
Duloxetine
|
Formulary
|
|
|
|
Gabapentin
(Neuropathic pain)
|
Formulary
|
|
|
|
Lidocaine 5% patches
|
Formulary
|
|
LMMG Recommendation - Neuropathic Pain
LMMG Recommendation - Post Herpetic Neuralgia
|
Pregabalin
(Neuropathic pain)
|
Formulary
|
|
|
|
|
|
|
|
| 04.07.03 |
Trigeminal neuralgia |
|
|
Carbamazepine
(Trigeminal neuralgia)
|
Formulary
|
|
|
|
| 04.07.03 |
Postherpetic neuralgia |
|
|
| 04.07.03 |
Chronic facial pain |
|
|
| 04.07.04 |
Antimigraine drugs |
|
|
Botulinum Toxin Type A
|
Formulary
|
|
|
|
| 04.07.04.01 |
Treatment of the acute migraine attack |
|
|
|
|
| 04.07.04.01 |
5HT1 agonists |
|
|
Rizatriptan (Maxalt®)
|
Formulary
|
|
|
|
Sumatriptan
|
Formulary
|
tablets/injection
|
|
|
Zolmitriptan
|
Formulary
|
|
|
|
| 04.07.04.01 |
Ergot alkaloids |
|
|
|
|
| 04.07.04.01 |
Other drugs for migrane |
|
|
| 04.07.04.02 |
Prophylaxis of migraine |
|
|
Topiramate
|
Formulary
|
migraine prophylaxis
|
|
|
| 04.07.04.03 |
Cluster headache |
|
|
|
|
|
|
| 04.08.01 |
Control of epilepsy |
|
|
Brivaracetam (Briviact®)
|
Formulary
|
|
|
|
| 04.08.01 |
Partial seizures with or without secondary generalisation |
|
|
| 04.08.01 |
Generalised seizures |
|
|
| 04.08.01 |
Carbamazepine and Oxcarbazepine |
|
|
Carbamazepine
|
Formulary
|
|
|
|
Eslicarbazepine (Zebinix®)
|
Formulary
|
|
|
|
Oxcarbazepine (Trileptal®)
|
Formulary
|
|
|
|
|
|
Ethosuximide
|
Formulary
|
|
|
|
| 04.08.01 |
Gabapentin and pregabalin |
|
|
Gabapentin
(Epilepsy)
|
Formulary
|
|
|
|
Pregabalin
(Epilepsy)
|
Formulary
|
|
|
|
| 04.08.01 |
Lacosamide |
|
|
Lacosamide (Vimpat ® )
|
Formulary
|
|
|
|
|
|
Lamotrigine
(epilepsy)
|
Formulary
|
Unlicensed use as a mood stabiliser
|
|
|
|
|
Levetiracetam
|
Formulary
|
RED for Levetiracetam infusion
|
|
|
|
|
| 04.08.01 |
Phenobarbital and other barbiturates |
|
|
Phenobarbital
|
Formulary
|
|
|
|
Primidone
|
Formulary
|
|
|
|
| 04.08.01 |
Phenytoin |
|
|
Phenytoin
(Oral)
|
Formulary
|
|
|
|
|
|
|
|
Rufinamide (Inovelon®)
|
Formulary
|
|
|
|
|
|
|
|
| 04.08.01 |
Topiramate |
|
|
Topiramate
|
Formulary
|
|
|
|
|
|
Sodium Valproate (Epilim®Epilim Chrono®)
|
Formulary
|
|
 Guideline: Sodium Valproate in women of child-bearing potential
|
|
|
Vigabatrin (Sabril®)
|
Formulary
|
|
|
|
|
|
Zonisamide (Zonegran®)
|
Formulary
|
|
|
|
|
|
Clobazam
|
Formulary
|
|
|
|
Clonazepam
(epilepsy/mood disorders)
|
Formulary
|
GREEN unlicensed anxiety
|
|
|
| 04.08.01 |
Other Drugs |
|
|
Perampanel (Fycompa®)
|
Formulary
|
|
NICE CG137: The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care
|
Retigabine
|
Formulary
|
|
NICE TA232: Retigabine for the adjunctive treatment of adults with partial onset seizures in epilepsy with and without secondary generalisation
|
| 04.08.02 |
Drugs used in status epilepticus |
|
|
Diazepam (epilepsy)
(rectal)
|
Formulary
|
|
|
|
Lorazepam
(injection - epilepsy)
|
Formulary
|
|
|
|
Midazolam (Buccolam®)
|
Formulary
|
|
|
|
Phenytoin
(IV)
|
Formulary
|
|
|
|
| 04.08.03 |
Febrile convulsions |
|
|
| 04.09 |
Drugs used in parkinsonism and related disorders |
|
|
|
|
| 04.09.01 |
Dopaminergic drugs used in Parkinsons disease |
|
|
| 04.09.01 |
Dopamine receptor agonists |
|
|
Apomorphine
|
Formulary
|
|
|
|
Cabergoline
|
Formulary
|
|
|
|
Pramipexole
|
Formulary
|
|
|
|
Ropinirole
|
Formulary
|
|
|
|
Rotigotine
|
Formulary
|
|
|
|
|
|
Co-Beneldopa (Madopar®)
|
Formulary
|
|
|
|
Co-Beneldopa (Madopar®CR)
|
Formulary
|
|
|
|
Co-Careldopa (Sinemet®)
|
Formulary
|
|
|
|
Co-Careldopa and Entacapone (Stalevo ®)
|
Formulary
|
|
|
|
Levodopa
|
Formulary
|
|
|
|
| 04.09.01 |
Monoamine-oxidase-B inhibitors |
|
|
Rasagiline
(Parkinsons disease)
|
Formulary
|
BLACK unlicensed MS
|
|
|
Selegiline Hydrochloride
|
Formulary
|
|
|
|
| 04.09.01 |
Catachol-O-methyltransferase inhibitors |
|
|
Entacapone (Comtess®)
(Adjunct to co-beneldopa or co-careldopa in Parkinson's disease)
|
Formulary
|
|
|
|
|
|
Amantadine
(Parkinson's)
|
Formulary
|
|
|
|
| 04.09.02 |
Antimuscarinic drugs used in parkinsonism |
|
|
Procyclidine
|
Formulary
|
|
|
|
Trihexyphenidyl
|
Formulary
|
|
|
|
| 04.09.03 |
Drugs used in essential tremor, chorea, tics, and related disorders |
|
|
Botulinum Toxin Type A
|
Formulary
|
Xeomin®; Dysport®; Botox®
|
|
|
Piracetam (Nootropil®)
|
Formulary
|
|
|
|
Riluzole (Rilutek®)
|
Formulary
|
|
NICE TA20: Motor neurone disease - riluzole
|
Tetrabenazine (Xenazine® 25)
|
Formulary
|
|
|
|
| 04.09.03 |
Torsion dystonias and other involuntary movements |
|
|
Botulinum Toxin Type A
|
Formulary
|
Xeomin®; Dysport®; Botox®
|
|
|
| 04.09.04 |
Restless leg syndrome |
|
|
Pramipexole
|
First Choice
|
|
|
|
Ropinirole
|
Formulary
|
|
|
|
Rotigotine
|
Formulary
|
|
|
|
Gabapentin
|
Unlicensed
|
|
|
|
Pregabalin
|
Unlicensed
|
|
|
|
|
|
| 04.10 |
Drugs used in substance dependence |
|
|
Thiamine
|
Formulary
|
Drug included within CCG low priority prescribing policy. EXEMPTIONS EXIST FOR CERTAIN INDICATIONS. Please consult attached policy for list of excepted indications for prescribing of this drug.
|
|
|
Vitamin B substances with ascorbic acid (Pabrinex®)
|
Formulary
|
|
|
|
| 04.10 |
Alcohol dependence |
|
|
Chlordiazepoxide
(substance dependence)
|
Formulary
|
|
|
|
|
|
Nicotine (Nicorette® Invisi patches)
|
Restricted
|
|
|
|
|
|
| 04.10.01 |
Alcohol dependence |
|
|
|
|
|
|
| 04.10.02 |
Nicotine dependence |
|
|
| 04.10.03 |
Opioid dependence |
|
|
|
|
| 04.10.03 |
Opioid substitution therapy |
|
|
Buprenorphine (Subutex®)
|
Formulary
|
|
|
|
Methadone
(Dependance )
|
Formulary
|
|
|
|
|
|
| 04.10.03 |
Adjunctive therapy and symptomatic treatment |
|
|
| 04.10.03 |
Opioid-receptor antagonists |
|
|
Naltrexone (Nalorex®)
(opioid dependence)
|
Formulary
|
|
NICE TA115: Drug misuse - naltrexone
|
|
|
Donepezil
|
First Choice
|
Tablet, Orodispersible Tablet, Oral Solution
|
|
|
Rivastigmine
|
Formulary
|
Capsule, Oral Solution, Transdermal Patch
|
|
|
Galantamine
|
Formulary
|
Tablet, Modified Release Capsule, Oral Solution
|
|
|
Memantine
|
Formulary
|
Tablet, Orodispersible Tablet, Oral Solution
|
|
|
|
|
|
|
| .... |
Key |
|
|
|
|
Cytotoxic Drug
|
|
|
Controlled Drug
|
|
High Cost Medicine
|
|
Cancer Drugs Fund
|
|
NHS England |
|
Homecare |
|
CCG |
|
Traffic Light Status Information
|
|
|
